Synthesis of compounds with potential central nervous system stimulant activity. II. 5-Spiro-substituted 2-amino-2-oxazolines
✍ Scribed by Harnden, Michael R.; Rasmussen, Ray R.
- Book ID
- 120777109
- Publisher
- American Chemical Society
- Year
- 1970
- Tongue
- English
- Weight
- 462 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0022-2623
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## Abstract 5,8‐Methanoquinazolines fused with 1,2,4‐triazole 4–5, tetrazole 6, and 1,2,4‐triazine 8 were prepared starting from 2‐hydrazino‐5,8‐methanoquinazoline 3. Compound 3 and 6 showed the most potent central nervous system (CNS) stimulant activities.
## Abstract Starting from 3‐chloro‐5,8‐methanoquinazoline **1** and 3‐chloro‐bornano[1,2,4]triazine **7**, the novel 5,8‐methanoquinazolines **5a‐b** and bornano[1,2,4]triazines **10a‐b** fused with imidazole and pyrimidine were prepared. None of these compounds showed any satisfactory central nerv