Synthesis of Chiral 2′,3′-Pyranone(pyrrolidinone)-fused Tryptamines.
✍ Scribed by Emmanuel Dardennes; Arpad Kovacs-Kulyassa; Andrea Renzetti; Janos Sapi; Jean-Yves Laronze
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 66 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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An efficient synthesis of 2-pyrrolidinone and N-methyl-2-pyrrolidinone was developed in which the compounds can be labeled with tritium at either the 3-and 4-positions or the 4-position of the lactam ring. Cyclization of [2 3-3Hl-yarninobutyric acid (GABA) yielded [ 3, $-$I -2pyrrolidinone and cycli
Asymmetric Synthesis of 2,3-Dihydro-4-pyranones by Reaction of Chiral 3-Alkoxycyclobutanone and Aldehydes. -The cyclobutanone (I) bearing L-ethyl lactate as chiral auxiliary is found to be highly suitable for the preparation of the pyran derivatives with good to excellent e.e. values. -(NEGISHI, S.;