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Synthesis of cephems bearing olefinic sulfoxide side chains as potential β-lactamase inhibitors

✍ Scribed by Vittorio Farina; Sheila I. Hauck; Raymond A. Firestone

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 266 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00285-5

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✦ Synopsis

Several cephems bearing vinyl sulfoxide and suffone moieties at C-3 were prepared by the Stille coupling of a 3-trifloxy cephem with stannanes. The sulfoxides were designed to be suicide lactamase inhibitors. None of the cephems described in this study functioned as an enzyme inhibitor, but two derivatives displayed interesting biological activity against Methycillin -resistant S. Aureus.

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