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Synthesis and Preliminary Biological Evaluation of 3′-Substituted Cephem Sulfones as Potential β-Lactamase Inhibitors

✍ Scribed by Francesco De Angelis; Giuseppe Attorrese; Giancarlo Cavicchio; Sabatino Ciampa; Alessandra Di Tullio; Daniela Fattori; Rosario Nicoletti; Enrico Domenici


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
298 KB
Volume
2001
Category
Article
ISSN
1434-193X

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## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐