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Synthesis and biological evaluation of 6-azabicyclo[3.2.0]hept-2-ene derivatives as potential anti-bacterial agents and β-lactamase inhibitors

✍ Scribed by Rajinder Singh; R.D.G Cooper

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
967 KB
Volume
50
Category
Article
ISSN
0040-4020

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✦ Synopsis

This paper describes the synthesis of a series of 6-azabicyclo[3 .2.0]hept-2-ene compounds and subsequent results obtained from biological testing, for anti-microbial potency and fi-lactamase inhibition activity . It was determined that a number of compounds possessed some J3-lactamase inhibition efficacy .

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## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐