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Synthesis of carbon-14 and tritium labeled N,N′-(2-chloro-5-cyano-1,3-phenylene)dioxamic acid di-tham salt

✍ Scribed by Richard S. P. Hsi; Tommy D. Johnson

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
401 KB
Volume
14
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Acetylation of tritium and carbon‐14 labeled 4‐chloro‐3,5‐diaminobenzonitrile (Ia and Ib) with ethyl oxalyl chloride afforded diethyl N,N′‐(2‐chloro‐5‐cyano‐1,3‐phenylene)dioxamate (IIa and IIb). The diester II was hydrolyzed to give N,N′‐(2‐chloro‐5‐cyano‐1,3‐phenylene)dioxamic acid, which was isolated as the tris‐hydroxymethylaminomethane (THAM) salt III.

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