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Synthesis of carbon-13 labelled 6-substituted benzo (a) pyrenes

✍ Scribed by Robert E. Royer; Guido H. Daub; David L. Vander Jagt

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
170 KB
Volume
12
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Sodium formate‐^13^C, prepared by hydrolysis of isopropyl formate, was allowed to react with N‐methylaniline hydrochloride to prepare the formylating agent N‐methylformanilide‐1‐^13^C. Formylation of benzo(a)pyrene with N‐methylformanilide‐1‐^13^C gave the 6‐^13^CHO derivative which was reduced to 6‐^13^CH~3~ and 6‐^13^CH~2~OH benzo(a)pyrenes. 6‐^13^CH~2~C1 benzo(a)pyrene was prepared from the 6‐^13^CH~2~OH derivative.

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