✦ LIBER ✦

Synthesis of C8–C8/C2–C8-linked triazolo pyrrolobenzodiazepine dimers by employing ‘click’ chemistry and their DNA-binding affinity

✍ Scribed by Ahmed Kamal; S. Prabhakar; N. Shankaraiah; Ch. Ratna Reddy; P. Venkat Reddy

Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 149 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.04.006

No coin nor oath required. For personal study only.

✦ Synopsis

A series of 1,2,3-triazole-containing pyrrolo[2,1-c][1,4]benzodiazepine dimers have been prepared efficiently by employing a 'click' chemistry protocol. This method involves 1,3-dipolar cycloaddition of terminal alkynes with organic azides using a Cu(I)-catalyst. Further, these molecules exhibited interesting DNA-binding affinity profiles.

📜 SIMILAR VOLUMES

Synthesis of C8-Linked Pyrrolo[2,1-c][1,

Synthesis of C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole Conjugates (I) with Remarkable DNA-Binding Affinity.

✍ Ahmed Kamal; P. Ramulu; O. Srinivas; G. Ramesh; P. Praveen Kumar 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 11 KB 👁 1 views

Synthesis of Novel C2 and C2—C8 Linked P

Synthesis of Novel C2 and C2—C8 Linked Pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide Hybrids as DNA-Binding Agents.

✍ Ahmed Kamal; O. Srinivas; P. Ramulu; G. Ramesh; P. Praveen Kumar 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 70 KB 👁 1 views

Synthesis of novel C2 and C2–C8 linked p

Synthesis of novel C2 and C2–C8 linked pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide hybrids as DNA-binding agents

✍ Ahmed Kamal; O. Srinivas; P. Ramulu; G. Ramesh; P.Praveen Kumar 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 182 KB

ChemInform Abstract: Synthesis of a Nove

ChemInform Abstract: Synthesis of a Novel C2/C2′-exo Unsaturated Pyrrolobenzodiazepine Cross-Linking Agent with Remarkable DNA Binding Affinity and Cytotoxicity.

✍ Stephen J. Gregson; Philip W. Howard; Terence C. Jenkins; Lloyd R. Kelland; Davi 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 40 KB 👁 1 views

Synthesis of C8-Linked Pyrrolo[2,1-c][1,

Synthesis of C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine-Acridone/Acridine Hybrids as Potential DNA-Binding Agents.

✍ Ahmed Kamal; O. Srinivas; P. Ramulu; G. Ramesh; P. Praveen Kumar 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 12 KB 👁 1 views

Decarboxylation, during their aromatizat

Decarboxylation, during their aromatization by Pd/C, of some 3,4-octahydronaphtho-7,8-benzocoumarins : Synthesis of 1,2'-binaphthyls and 2,2'-binaphthyls

✍ K. Chebaane; M. Guyot 📂 Article 📅 1977 🏛 Elsevier Science 🌐 French ⚖ 311 KB