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Synthesis of C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole Conjugates (I) with Remarkable DNA-Binding Affinity.

✍ Scribed by Ahmed Kamal; P. Ramulu; O. Srinivas; G. Ramesh; P. Praveen Kumar


Publisher
John Wiley and Sons
Year
2004
Weight
11 KB
Volume
35
Category
Article
ISSN
0931-7597

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Synthesis of Sequence-Selective C8-Linked Pyrrolo(2,1-c)(1,4) benzodiazepine DNA Interstrand Cross-Linking Agents. -In order to construct the key A-ring fragments (VI), a versatile convergent approach is developed to join two units of vanillic acid (I) with Ξ±,Ο‰-dihaloalkanes (II). The "amino-thioac