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Synthesis of C- and N-nucleosides and use of distance geometry approach for the evaluation of in vitro antiviral activity

โœ Scribed by J Kobe; B Kobe; M Prhave; A Stimac; T Solmajer


Book ID
118392498
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
49 KB
Volume
15
Category
Article
ISSN
0166-3542

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Acyclic analogs of nucleosides. Synthesi
โœ A. รฉ. Yavorskii; A. V. Turov; I. V. Gogoman; A. I. Sobko; V. N. Tatskaya; V. G. ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Springer US ๐ŸŒ English โš– 261 KB

In a search for novel antiviral compounds of the 'doubly modified' nucleoside type, we have prepared 1-(4-hydroxy-2-oxabutyl)-, 1-(4-hydroxy-3-hydroxymethyl-2-oxabutyl)-, 1-(4-hydroxy-1-hydroxymethy1-2-oxabutyl)-, 1-(4-hydroxy-1-methyl-2-oxabutyl), 1-(4,5-dihydroxy-2-oxapentyl)-, 1-(5-hydroxy-2-oxap