𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Acyclic analogs of nucleosides. Synthesis and in vitro antiviral activity of hydroxyalkyl-2-(trifluoromethylthiomethyl) benzimidazoles

✍ Scribed by A. é. Yavorskii; A. V. Turov; I. V. Gogoman; A. I. Sobko; V. N. Tatskaya; V. G. Kvachev; V. L. Florent'ev

Publisher
Springer US
Year
1989
Tongue
English
Weight
261 KB
Volume
25
Category
Article
ISSN
0009-3122

No coin nor oath required. For personal study only.

✦ Synopsis

In a search for novel antiviral compounds of the 'doubly modified' nucleoside type, we have prepared 1-(4-hydroxy-2-oxabutyl)-, 1-(4-hydroxy-3-hydroxymethyl-2-oxabutyl)-, 1-(4-hydroxy-1-hydroxymethy1-2-oxabutyl)-, 1-(4-hydroxy-1-methyl-2-oxabutyl), 1-(4,5-dihydroxy-2-oxapentyl)-, 1-(5-hydroxy-2-oxapentyl), 1-(5-hydroxy-1-chloromethyl-2-oxapentyl)-, and 1-(6-hydroxy-1-chloromethyl-2-oxahexyl)-2-(trifluoromethylthiomethyl)benzimidazole. They were obtained by condensing the trimethylsilyl derivative of 2-(trifluoromethylthiomethyl) benzimidazole with alkylating agents in the presence of an equimolar mixture of trifluoromethanesulfonic acid and trimethylchlorosilane. These nucleoside analogs showed moderate antiviral activity against some RNA viruses.

📜 SIMILAR VOLUMES

Synthesis and antitumor activity of new
Synthesis and antitumor activity of new 1,2,4-triazine and [1,2,4]triazolo[4,3-b][1,2,4]triazine derivatives and their thioglycoside and acyclic C-nucleoside analogs
✍ Wael A. El-Sayed; Ibrahim F. Nassar; Adel A.-H. Abdel-Rahman 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 167 KB

## Abstract New 1,2,4‐triazine and their derived 1,2,4‐triazolo[3,4‐__b__][1,2,4]triazine derivatives were synthesized starting from 5,6‐diphenyl‐1,2,4‐triazine‐3‐thiol. Furthermore, the corresponding 1,2,4‐triazolo[3,4‐__b__][1,2,4]‐triazine thioglycosides and acyclic __C__‐nucleoside analogs were