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Synthesis of bis(glycosylamino)alkanes and bis(glycosylamino)arenes

โœ Scribed by S. V. Metlitskikh; A. M. Koroteev; M. P. Koroteev; A. S. Shashkov; A. A. Korlyukov; M. Yu. Antipin; A. I. Stash; E. E. Nifantiev


Book ID
106519994
Publisher
Springer
Year
2005
Tongue
English
Weight
376 KB
Volume
54
Category
Article
ISSN
1573-9171

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โœฆ Synopsis


The condensation of D mannose and D galactose with aliphatic and aromatic diamines afforded a series of bis(glycosylamino)alkanes and arenes. A possible mechanism was pro posed for the formation of 1,2 bis(ฮฒ D glycosylamino)benzenes.


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In connection with structural modification of the trehalase inhibitor trehazolin (1), as a new-type of glycohydrolase inhibitor, some glycosylamino-oxazolines were designed and synthesized. Among three oxazolines beta-galacto (3), beta-gluco (5) and alpha-manno-types (6) obtained in stable form, the