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Synthesis of azathia analogues of platelet activating factor with polyheterosidechains

✍ Scribed by J.M. Zeidler; W. Zimmermann; H.J. Roth

Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 417 KB
Volume: 55
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(90)90076-4

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✦ Synopsis

The synthesis of azathia analogues of the platelet activating factor with oxygen and sulphur-containing sidechains is reported. The starting point is 1-acetylthio-3-hydroxy-2-propaneamine-HCl, which permits the formation of the thioether and the acetamido linkage in one step. The phosphocholine part is introduced via 2-chloro-2-oxo-l,3,2-dioxaphospholane and subsequent ring opening with trimethylamine under pressure.

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