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Synthesis of aspartame via asymmetric hydrogenation of N-protected (Z)-N-.alpha.-L-aspartyl-.DELTA.-phenylalanine methyl ester

✍ Scribed by Fuganti, Claudio; Grasselli, Piero; Malpezzi, Luciana; Casati, Paolo


Book ID
126300283
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
464 KB
Volume
51
Category
Article
ISSN
0022-3263

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A novel approach to the synthesis of labelled (2H, ~H) peptides through the catalytic asymmetric reduction of AZTrp containing peptides, using rhodium complexes with chiral diphosphine ligands as the catalysts, is described. Ac-AZTrp-(L)-Phe-OMe is used as a model substrate to study this new route.