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Catalytic asymmetric synthesis of methyl ester of N-acetyl-α-phenylalanine on chiral cobalt complexes

✍ Scribed by L. O. Nindakova; F. K. Shmidt; E. I. Klabunovskii; V. A. Pavlov


Book ID
112456721
Publisher
Springer
Year
1984
Tongue
English
Weight
220 KB
Volume
33
Category
Article
ISSN
1573-9171

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A novel approach to the synthesis of labelled (2H, ~H) peptides through the catalytic asymmetric reduction of AZTrp containing peptides, using rhodium complexes with chiral diphosphine ligands as the catalysts, is described. Ac-AZTrp-(L)-Phe-OMe is used as a model substrate to study this new route.