Asymmetric syntheses of&-hydroxy carboxylic acids have gathered much interest for a long time, and a large number of reports have been made on the Grignard reaction and the reduction of&-keto esters. 1 As for the asymmetric reduction of&-keto esters, catalytic hydrogenation and metal hydride reducti
The asymmetric hydrogenation of α-keto esters catalyzed by rhodium(I) complexes with chiral diphosphine ligands. On the catalytic cycles and the mechanism of asymmetric induction
✍ Scribed by Iwao Ojima; Tetsuo Kogure
- Book ID
- 108351657
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 705 KB
- Volume
- 195
- Category
- Article
- ISSN
- 0022-328X
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## Abstract The development of Ir‐catalyzed asymmetric hydrogenation of α‐amino‐β‐keto ester hydrochlorides is described. This reaction proceeds through a dynamic kinetic resolution to produce __anti__‐β‐hydroxy‐α‐amino acid esters in a high diastereo‐ and enantioselective manner. Mechanistic studi
The applications of the chiral dipyridylphosphine ligand P-Phos and its derivatives Tol-P-Phos and Xyl-P-Phos in Ruand Rh-catalyzed hydrogenations of the methyl esters of a variety of (Z)-2-acetamido-3-arylacrylic acids have been studied systematically. The results show that the electronic and steri