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Continuous Synthesis of N-(Benzyloxycarbonyl)-L-Aspartyl-L-Phenylalanine Methyl Ester with Immobilized Thermolysin in an Organic Solvent

โœ Scribed by Nakanishi, K. ;Kamikubo, T. ;Matsuno, R.


Book ID
126770580
Publisher
Nature Publishing Group
Year
1985
Tongue
English
Weight
671 KB
Volume
3
Category
Article
ISSN
1087-0156

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Aspartyl-L-phenylalanine methyl and ethyl esters were synthesised enzymatically in toluene by means of the zinc protease thermolysin adsorbed onto Celite R-640 ยฎ , which is a porous support able to control the hydration of the protein. The conversion of the two derivatised amino acids into the desir