Synthesis of aromatic 1,2-diazines by inverse electron demand Diels-Alder reaction of polymer-supported 1,2,4,5-tetrazines
β Scribed by James S. Panek; Bin Zhu
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 236 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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Inverse Electron Demand Diels-Alder Reactions of 3,6-Dichloro-[1,2,4,5]tetrazine. -Tetrazine (I) is used as an azadiene equivalent for inverse electron demand Diels -Alder reactions with alkynes and alkenes to give functionalized dichloropyridazines, e.g. (III), (V), and (VII). -(SPAREY, T.
The selective preparation of 3-methoxy-6-methylthio-l,2,4,5-tetrazine (2) and 3,6-dimethoxy-l,2,4,5-tetrazine (3) from 3,6Β°bis(methylthio)-l,2,4,5-tetrazine (1) is described. A preliminary investigation into the participation of 2 in [4+2] cycloaddition reactions with electron rich and neutral dieno