Anatoxin-a analogue was prepared by resolution of aminoacid 1 using chiral (R)-4-phenyl-oxazolidin-2thione as derivatizing agent. X-ray diffraction of a diastereomer allowed us to determine its absolute configuration. The synthesis could then be completed in few steps followed by introduction of an
Synthesis of (±)-Anatoxin-a and Analogues
✍ Scribed by Philip J Parsons; Nicholas P Camp; Neil Edwards; L Ravi Sumoreeah
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 160 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
Anatoxin-a has been synthesized in 8 steps, starting from succinimide, 4-bromo-l--butene and dimethyl (2-oxopropyl)phosphonate, by employing as the key step an intramolecular reaction of an N-acyliminium precursor with an cu,&unsaturated ketone moiety, induced by saturated HCl in MeOH at -5OOC. Ana