Dethiobiotin synthetase (DTBS ; E.C. 6.6.6.6), the penultimate enzyme in the biosynthesis of the essential vitamin biotin, is a new potential target for novel herbicides. Inhibitors were designed based on mechanistic and structural information. The in-vitro activities of these potential inhibitors v
Synthesis of analogues of the monic acids A and C as potential herbicides
โ Scribed by Bellini, Peter; Clough, John M; Hatter, Glenn
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 139 KB
- Volume
- 55
- Category
- Article
- ISSN
- 1526-498X
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โฆ Synopsis
The synthesis of some analogues of pseudomonic acids with simpliรผed 'left-hand' sidechains is reported. Tested against isoleucyl tRNA, none was as active as methyl monate A and none was active as a herbicide in glasshouse tests.
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Methyl epiboxidineโ__N__โcarboxylate (**8**) was synthesized from **7** under reductive __Heck__ conditions (__Schemeโ 2__). The C๏ฃฟC coupling of the new epiboxidine analog **9** with aryl and heteroaryl halides gave by hydroarylation __C__โaryl, __N__โ(3โmethylisoxazolโ5โyl)โsubstituted
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