The Synthesis of Epiboxidine and Related Analogues as Potential Pharmacological Agents

✍ Scribed by Irem Kulu; Nuket Ocal

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: German
• Weight: 170 KB
• Volume: 94
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.201100140

✦ Synopsis

Abstract

Methyl epiboxidine‐N‐carboxylate (8) was synthesized from 7 under reductive Heck conditions (Scheme 2). The CC coupling of the new epiboxidine analog 9 with aryl and heteroaryl halides gave by hydroarylation C‐aryl, N‐(3‐methylisoxazol‐5‐yl)‐substituted tricyclic imides 10a–10f (Table). The [3+2] cycloaddition of 9 with nitrile oxides yielded the bridged dihydroisoxazole derivatives 11a–11d with potential biological activity (Scheme 4).