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Synthesis of analogs of farnesyl diphosphate

✍ Scribed by Julia M. Dolence; C. Dale Poulter

Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
741 KB
Volume
52
Category
Article
ISSN
0040-4020

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The synthesis and first antimicrobial evaluation of farnesyl diphosphate mimetics are described. Several analogues (10, 12, 13, and 20) are inhibitors of Candida albicans, Shizosaccharomyces pombe, and Saccharomyces cerevisiae. The activities of analogues 10, 12, and 13, which contain a omega-phenyl

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The substrate specificity of farnesyl diphosphate synthase from Bacillus stearothermophilus was studied and compared with that of the pig liver counterpart. Allylic diphosphate analogs having hydrocarbon chains were accepted as good substrates by both enzymes. However, the bacterial enzyme hardly ac