A practical synthesis of neuraminidase influenza inhibitor, A-322278, has been developed. Asymmetry is introduced into the synthesis by an enzyme mediated ester hydrolysis. A highly diastereoselective vinylogous Mannich condensation reaction of N-Boc-2-tert-butyldimethylsilyloxypyrrole (TBSOP) and a
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Synthesis of an Influenza Neuraminidase Inhibitor Intermediate via a Highly Diastereoselective Coupling Reaction
β Scribed by Barnes, David M.; McLaughlin, Maureen A.; Oie, Tetsuro; Rasmussen, Michael W.; Stewart, Kent D.; Wittenberger, Steven J.
- Book ID
- 120002775
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 48 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1523-7060
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