Highly effective synthesis of 4-halo-tetrahydropyrans via a highly diastereoselective in situ Prins-type cyclization reaction

✍ Scribed by Jun Yang; Ganapathy S. Viswanathan; Chao-Jun Li

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 173 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00027-1

✦ Synopsis

The reaction of aldehyde with homoaUyl alcohols mediated by indium trichloride generated 4-chlorotetrahydropyrans in high yields and with high stereoselectivity. The same type of compounds can be generated through a single step, multi-component coupling between aldehyde and allyl bromide mediated by indium O 1999 Elsevier Science Ltd. All rights reserved.