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Synthesis of an I-123 analog of A-85380 and preliminary SPECT imaging of nicotinic receptors in baboon

✍ Scribed by John L. Musachio; Victor L. Villemagne; Ursula A. Scheffel; Robert F. Dannals; A.Semih Dogan; Fuji Yokoi; Dean F. Wong


Book ID
117688349
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
298 KB
Volume
26
Category
Article
ISSN
0969-8051

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## Abstract In order to image nAChR density __in vivo__ in humans, [5‐^123^I]‐iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine ([5‐^123^I]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, __in vitro__ validation in human post‐mortem tissue and some in