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[123I]5-IA-85380 SPECT imaging nicotine occupancy of brain β2-nicotinic acetylcholine receptors after smoking low nicotine and nicotine-free cigarettes

✍ Scribed by Irina Esterlis; J.C. Batis; K.P. Cosgrove; F. Bois; S. McKee; T.A. Kloczynski; S.M. Stiklus; S. O'Malley; E. Perry; G.D. Tamagnan; J.P. Seibyl; J.K. Staley


Book ID
118491155
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
62 KB
Volume
41
Category
Article
ISSN
1053-8119

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## Abstract In order to image nAChR density __in vivo__ in humans, [5‐^123^I]‐iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine ([5‐^123^I]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, __in vitro__ validation in human post‐mortem tissue and some in