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Synthesis of an amidine pseudo-(1→6)-dimannoside and evaluation as a glycosidase inhibitor

✍ Scribed by Yves Blériot; Thierry Dintinger; Nathalie Guillo; Charles Tellier

Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
201 KB
Volume
36
Category
Article
ISSN
0040-4039

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Iminoheptitols as glycosidase inhibitors
Iminoheptitols as glycosidase inhibitors: Synthesis of α-homomannojirimycin, 6-epi-α-homomannojirimycin and of a highly substituted pipecolic acid
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In a search for a mannopyranose analogue which inhibits a-mannosidases but not a-fucosidases, ahomonojirimycin was prepared, the syntheses of 6-epi-a-homonojirimycin and of 2,6-dideoxy-2.6-imino-Lglycero-D-ralo-heptonic acid (a highly substituted pipecolic acid) are also reported.