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Synthesis and Evaluation as Glycosidase Inhibitors of 1H-Imidazol-2-yl C-Glycopyranosides

✍ Scribed by Thierry Granier; Andrea Vasella


Publisher
John Wiley and Sons
Year
1995
Tongue
German
Weight
670 KB
Volume
78
Category
Article
ISSN
0018-019X

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Synthesis of 1-(1H-Imidazol-2-yl)ethane-
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Compounds 6-13 were prepared starting from 1-(triphenlymethy1)-protected 1H-imidazoles 14 and 15 in several steps. Lithiation with BuLi in T H F followed by reaction with (triphcny1methoxy)acetaldehyde (16) afforded 17 and 18, respectively. 0-Methylation of 17 and 18 gave diethers 19 and 20, respect