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Synthesis and Evaluation as Glycosidase Inhibitors of Isoquinuclidines Mimicking a Distorted β-Mannopyranoside

✍ Scribed by Matthias Böhm; Edwige Lorthiois; Muthuppalaniappan Meyyappan; Andrea Vasella

Publisher
John Wiley and Sons
Year
2003
Tongue
German
Weight
444 KB
Volume
86
Category
Article
ISSN
0018-019X

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📜 SIMILAR VOLUMES

7-Oxanorbornane and Norbornane Mimics of
7-Oxanorbornane and Norbornane Mimics of a Distorted β-D-Mannopyranoside: Synthesis and Evaluation as β-Mannosidase Inhibitors
✍ Stephan Buser; Andrea Vasella 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 German ⚖ 293 KB

## Abstract The racemic 7‐oxanorbornanyl and norbornanyl aminoalcohols **3, 4, 42, 45**, and **46** were synthesized and tested as snail __β__‐mannosidase inhibitors. The amino tetraol **3** was obtained from the known sulfonyl acrylate **9** and furan **10**. Esterification provided **11** that un