We wish to report our first studies on the possibility of applying the acetoacetyl group CHzCOCHzCC-(AA), to the protection of amino groups in peptide synthesis.
Synthesis of amino acyl adenylates using thetert-butoxycarbonyl protecting group
โ Scribed by Daniel W. Armstrong; Russell Seguin; Masahiko Saburi; Janos H. Fendler
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 514 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0022-2844
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
In this communication we introduce a promising masking agent --the vinyloxycarbonyl or VOC group --for the protection of amino functions in peptide chemistry. Amino acids are easily converted to their N-VOC derivatives (l\_) in dilute aqueous base using the known vinyl chloroformate' in dioxane as t
One of the major problems,in oligonucleotide synthesis is the design of suitable protecting groups for the reactive hydroxyl and amino functions of nucleosides and nucleotides. Ideally, these protecting groups should satisfy the following conditions: 1) they should be stable under the reaction cond