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Enzymatic removal of acyl protecting groups. The use of dihydrocinnamoyl group in oligonucleotide synthesis and its cleavage by α-chymotrypsin

✍ Scribed by H.S. Sachdev; N.A. Starkovsky

Publisher
Elsevier Science
Year
1969
Tongue
French
Weight
204 KB
Volume
10
Category
Article
ISSN
0040-4039

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✦ Synopsis

One of the major problems,in oligonucleotide synthesis is the design of suitable protecting groups for the reactive hydroxyl and amino functions of nucleosides and nucleotides.

Ideally, these protecting groups should satisfy the following conditions: 1) they should be stable under the reaction conditions; 2) they should be removable under essentially neutral conditions, and 3) they should display selectivity for the one or the other of the hydroxyl or amino functions.

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