✦ LIBER ✦
New improvements in oligonucleotide synthesis by use of the p-nitrophenylethyl phosphate blocking group and its deprotection by DBU or DBN
✍ Scribed by Eugen Uhlmann; Wolfgang Pfleiderer
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- French
- Weight
- 227 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Phosphate protection in the phosphotriester approach is improved by the new, versatile p-nitrophenylethyl group due to its stability in the condensation step and its clean removal by DBU and DBN respectively.
Recent investigations in the field of oligonucleotide synthesis [l-4] have re-