Synthesis of C15,14%-ring locked all-trans-b-carotene is described. The symmetric nature of the b-carotene analog allowed for rapid construction of the carbon frame through bis-olefination of the central dialdehyde containing the ring functionality with a C15 ylide bearing the ionone moiety.
Synthesis of all-trans-beta-carotene retinoids and derivatives labelled with 14C
✍ Scribed by El-mostafa Azim; Philippe Auzeloux; Jean-Claude Maurizis; Véronique Braesco; Pascal Grolier; Annie Veyre; Jean-Claude Madelmont
- Book ID
- 102659560
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- French
- Weight
- 576 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
In this paper we report the synthesis of all-trans Retinoic acid, Retinal, Retinol specifically labelled with I4C at position 7 and all-trans Beta-carotene labelled at positions 7 and 7', with more than 98 % radiochemical purity. All products were obtained with about 15 % overall yield from I4C sodium cyanide. CCC 0362-4803/96/050441-11 01996 by John Wiley &Sons, Ltd.
📜 SIMILAR VOLUMES
Isobutyl [3-14C] cyanoacrylate and diethyl [3-14C] methylidenemalonate were synthesized by the intermediate of their protective Diels-Alder adduct with anthracene. These adducts (&&,I were obtained in a one-pot procedure by Knoevenagel condensation of p4C] paraformaldehyde with isobutyl cyanoacetate
## Abstract The cytotoxic antitumor compound PNU‐159548 (**1**) has been labelled with ^14^C and ^2^H. A three‐step sequence starting from [14‐^14^C]idarubicin (**2a**) led to radiochemically pure (>98%) [14‐^14^C]PNU‐159548 with a specific activity of 1.13 GBq/mmol. The synthesis of [^2^H~4~]PNU‐1