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The isolation and determination of the structure of thienamycin together with the discovery of the monobactam antibiotics gave renewed impetus to the synthesis of plactams.
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2-hydroxyphenyl)-2,4dimethyl-1,5-pentanediones / NMR spectroscopy The diastereoselective synthesis of 3-aryl-1,5-bis(2-hydroxypropiophenone with appropriate benzaldehyde derivatives. The structures and stereochemistry of the hydroxyphenyl)-2,4-dimethyl-1,5-pentanediones has been carried out by conj
Synthesis of 5-[(Indol-2-on-3-yl)methyl]-2,2-dimethyl-1,3-dioxane-4,6diones and Spirocyclopropyloxindole Derivatives. Potential Aldose Reductase Inhibitors. -Indoles (I) are transformed into indolyl derivatives (IV) following a literature process. Subsequent reaction with 1 equiv. of NBS generates