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Diastereoselective Conjugate Addition Reactions of 2′-Hydroxypropiophenone to 2′-Hydroxychalcones – Synthesis and Structural Characterization of the Diastereomers of (±)-3-Aryl-1,5-bis(2-hydroxyphenyl)-2,4-dimethyl-1,5-pentanediones

✍ Scribed by Artur M. S. Silva; Lúcia M. P. M. Almeida; Hilário R. Tavares; José A. S. Cavaleiro

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
233 KB
Volume
1999
Category
Article
ISSN
1434-193X

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✦ Synopsis

2-hydroxyphenyl)-2,4dimethyl-1,5-pentanediones / NMR spectroscopy

The diastereoselective synthesis of 3-aryl-1,5-bis(2-hydroxypropiophenone with appropriate benzaldehyde derivatives. The structures and stereochemistry of the hydroxyphenyl)-2,4-dimethyl-1,5-pentanediones has been carried out by conjugate addition reactions of 2Ј-obtained diastereomers have been determined using various NMR techniques, and the factors determining their formation hydroxypropiophenone to 2Ј-hydroxy-α-methylchalcone derivatives, or in single one-pot reactions of 2Ј-are investigated and discussed.

natural compounds that can be found in a number of higher diastereomer of the corresponding 1,5-pentanedione. This

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