𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of alkylated iridolactone analogs

✍ Scribed by Zineb Guerrab; Boujemaâ Daou; Souad Fkih-Tetouani; Mohammed Ahmar; Bernard Cazes

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
190 KB
Volume
44
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Bicyclic d-lactones, iridolactones analogs with an alkyl group at the bicyclic junction, are obtained from a-alkyl-ahydroxymethylcyclopentanones via an intramolecular Horner-Wadsworth-Emmons reaction.

📜 SIMILAR VOLUMES

Synthesis of C-3 alkyl analogs of cocain
Synthesis of C-3 alkyl analogs of cocaine
✍ Shi Xian Deng; Dan Wen Huang; Donald W Landry 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 63 KB

The first general stereocontrolled approach to C-3 alkyl analogs of cocaine is described. The route utilized versatile intermediates 2b-hydroxymethyl-3a-cyanotropane and 2b-hydroxymethyl-3b-cyanotropane.

Synthesis and pharmacology of 2-alkyl ra
Synthesis and pharmacology of 2-alkyl raloxifene analogs
✍ Timothy A. Grese; Stephen Cho; Henry U. Bryant; Harlan W. Cole; Andrew L. Glaseb 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 290 KB

A series of 2-alkyl and 2-cycioalkyl raloxifene analogs have been prepared and evaluated in both in vitro and in vivo models of estrogen/antiestrogen activity. In particular, the 2-cyclohexyl analogs show promise as potent sdective estrogen-receptor modulators (SERMs). The decreased production of o