Synthesis of alkylaminoalkylamides of substituted 2-aminopyrroles as potential local anesthetic and antiarrhythmic agents I: α-Amines
✍ Scribed by J. Walter Sowell Sr.; Mary Elizabeth Derrick; John J. Freeman; Ronald J. Mattson; Joseph W. Kosh; Philip F. Mubarak; Alan J. Block; Paul A. Tenthorey
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 614 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Synthesis and Biological Evaluation of New Cyclopenteno[b]thiophene Derivatives as Local Anesthetic and Antiarrhythmic Agents. -A series of new 2-aminocyclopentenothiophene-3-carboxylates such as (V) and (VI) (12 examples in all) are synthesized as carticaine analogues. Compounds (Va), (Vc), (Vd), (
The aliphatic amines. 2-methyl-and 2-isopropyl-substituted 6-hydroxy-1-hexylamines were synthesized from ethyl-6-hydroxyhexanoate in 22% and 11% overall chemical yield respectively. 6-hydroxy-1 -hexylamine was available commercially. 6-hydroxy -l -hexylamine and its 2-methyl-and 2-isopropyl-substitu
The aliphatic amines. o-phenylpmylamine and its 8-methyl substituted analogue were synthesized from o-phenylpentanoic acid in 34.7% and 28.5% overall chemical yield rcspectivcly. y -Methyl -a-phenylpentylamine was prepared from o-phenylbutyric acid in 39.5% overall chemical yield. Radioiodination of