Radioiodinated aliphatic amines as potential pulmonary imaging agents: II. Synthesis of ω-(4-[131I]-iodophenyl)pentylamine and its β- and γ-Methyl substituted analogues

✍ Scribed by Y. W. Lee; G. Gopalakrish; S. F. P. Man; A. A. Noujaim

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: French
• Weight: 535 KB
• Volume: 25
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580250605

✦ Synopsis

The aliphatic amines. o-phenylpmylamine and its 8-methyl substituted analogue were synthesized from o-phenylpentanoic acid in 34.7% and 28.5% overall chemical yield rcspectivcly. y -Methyl -a-phenylpentylamine was prepared from o-phenylbutyric acid in 39.5% overall chemical yield. Radioiodination of the amines with thallium trifluoroacetate and no-carrier-added [1311]-Nal afforded the corresponding [1311]-labelled amines in 309b. 28% and 36% radiochemical yield respectively and greater than 98% radiochemical purity (calculated specific activity 20 -40 TBqmmol-l). The position of iodination was established by proton magnetic resonance to be para to the alkyl chain.