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Synthesis of adenylyl-(2′→5′)-adenylyl-(2′→5′)-adenosine (2-5A core)

✍ Scribed by J.B. Chattopadhyaya


Publisher
Elsevier Science
Year
1980
Tongue
French
Weight
285 KB
Volume
21
Category
Article
ISSN
0040-4039

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Nucleotides part XXX Chemical synthesis
✍ Ramamurthy Charubala; Wolfgang Pfleiderer; Robert W. Sobol; Shi Wu Li; Robert J. 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 German ⚖ 511 KB

The chemical synthesis of adenylyl-(2-5')-adenylyl-(2-5')-8-azidoadenosine (15) was performed by the phosphotriester approach. Enzymatic phosphorylation of 15 by [y -3ZP]ATP led to the corresponding labelled 5'monophosphate 16. Photoinsertion of 16 took place on UV irradiation by covalent cross link