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Synthesis of active metabolites of indole pyrrolothiazole paf antagonists

โœ Scribed by Steven K. Davidsen; James B. Summers; David J. Sweeny; James H. Holms; Daniel H. Albert; George M. Carrera Jr.; Paul Tapang; Terrance J. Magoc; Richard G. Conway; David A. Rhein

Book ID
108038923
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
269 KB
Volume
5
Category
Article
ISSN
0960-894X

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๐Ÿ“œ SIMILAR VOLUMES

Synthesis and evaluation of water solubl
Synthesis and evaluation of water soluble indole pyrrolothiazole paf antagonists
โœ George S. Sheppard; Steven K. Davidsen; George M. Carrera Jr.; Daisy Pireh; Jame ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 320 KB

3-(3-Pyridinyl)-7-(indol-3-ylcarbonyl)-lH-3H-pyrrolo[1,2-c]thiazoles represent a class of potent, orally active PAF antagonists; however, the lead compounds in this series suffered from a lack of aqueous solubility. To overcome this limitation, a number of strategies were examined to achieve improve

Discovery and optimization of indole pyr
Discovery and optimization of indole pyrrolothiazole paf antagonists
โœ James H. Holms; Steven K. Davidsen; George S. Sheppard; George M. Carrera Jr.; N ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 303 KB

3-(3-Pyridinyl)-7-(indol-3-ylcarbonyl)-lH-3H-pyrrolo[l,2-c]thiazoles represent a new class of platelet activating factor antagonists. This series was discovered by combining the indole portion of a previous thiazolidine series with the known 3-pyridi~yl-pyrrolothiazole pharmacophore. Optiraization o