Synthesis and evaluation of water solubl
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George S. Sheppard; Steven K. Davidsen; George M. Carrera Jr.; Daisy Pireh; Jame
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Article
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1995
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Elsevier Science
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English
โ 320 KB
3-(3-Pyridinyl)-7-(indol-3-ylcarbonyl)-lH-3H-pyrrolo[1,2-c]thiazoles represent a class of potent, orally active PAF antagonists; however, the lead compounds in this series suffered from a lack of aqueous solubility. To overcome this limitation, a number of strategies were examined to achieve improve