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ChemInform Abstract: Synthesis and Evaluation of Water Soluble Indole Pyrrolothiazole PAF Antagonists.

โœ Scribed by G. S. SHEPPARD; S. K. DAVIDSEN; G. M. JUN. CARRERA; D. PIREH; J. H. HOLMS; H. R. HEYMAN; D. H. STEINMAN; M. L. CURTIN; R. G. CONWAY; D. A. RHEIN; D. H. ALBERT; P. TAPANG; T. J. MAGOC; J. B. SUMMERS


Book ID
112029882
Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis and evaluation of water solubl
โœ George S. Sheppard; Steven K. Davidsen; George M. Carrera Jr.; Daisy Pireh; Jame ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 320 KB

3-(3-Pyridinyl)-7-(indol-3-ylcarbonyl)-lH-3H-pyrrolo[1,2-c]thiazoles represent a class of potent, orally active PAF antagonists; however, the lead compounds in this series suffered from a lack of aqueous solubility. To overcome this limitation, a number of strategies were examined to achieve improve