Synthesis of a well-defined glycopolymer by atom transfer radical polymerization

✍ Scribed by Kohji Ohno; Yoshinobu Tsujii; Takeshi Fukuda

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 221 KB
• Volume: 36
• Category: Article
• ISSN: 0887-624X
• DOI: 10.1002/(sici)1099-0518(199810)36:14<2473::aid-pola5>3.0.co;2-u

✦ Synopsis

Controlled free radical polymerization of sugar-carrying methacrylate, 3-Omethacryloyl-1,2 : 5,6-di-O-isopropylidene-D-glucofuranose (MAIpGlc) was achieved by the atom transfer radical polymerization (ATRP) technique with an alkyl halide/coppercomplex system in veratrole at 80°C. The time-conversion first-order plot was linear and the number-average molecular weight increased in direct proportion to the ratio of the monomer conversion to the initial initiator concentration, providing PMAIpGlc with a low polydispersity. The sequential addition of the two monomers styrene (S) and MAIpGlc afforded a block copolymer of the type PS-b-PMAIpGlc. The acidolysis of the homo-and block copolymers gave well-defined glucose-carrying water-soluble polymers PMAGlc and PS-b-PMAGlc, respectively. The amphiphilic PS-b-PMAGlc block copolymer exhibited a microdomain surface morphology with spherical PS domains in a PMAGlc matrix.