Synthesis of a TRPV1 Receptor Antagonist
β Scribed by Yu, Su; Haight, Anthony; Kotecki, Brian; Wang, Lei; Lukin, Kirill; Hill, David R.
- Book ID
- 119962597
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 749 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
A highly efficient asymmetric synthesis of TRPV1 antagonist ABT-102 was developed and successfully demonstrated on a multi-kilogram scale. This process incorporates a new asymmetric synthesis of (R)-tert-butylaminoindan, which is based on a chiral auxiliary induced diastereoselective reduction of it
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