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Synthesis of a TRPV1 Receptor Antagonist

✍ Scribed by Yu, Su; Haight, Anthony; Kotecki, Brian; Wang, Lei; Lukin, Kirill; Hill, David R.


Book ID
119962597
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
749 KB
Volume
74
Category
Article
ISSN
0022-3263

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Development of a Large Scale Asymmetric
✍ Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatram πŸ“‚ Article πŸ“… 2007 πŸ› American Chemical Society 🌐 English βš– 104 KB

A highly efficient asymmetric synthesis of TRPV1 antagonist ABT-102 was developed and successfully demonstrated on a multi-kilogram scale. This process incorporates a new asymmetric synthesis of (R)-tert-butylaminoindan, which is based on a chiral auxiliary induced diastereoselective reduction of it