๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Process Development and Multikilogram-Scale Synthesis of a TRPV1 Antagonist

โœ Scribed by Cleator, Ed; Scott, Jeremy P.; Avalle, Paulo; Bio, Matthew M.; Brewer, Sarah E.; Davies, Antony J.; Gibb, Andrew D.; Sheen, Faye J.; Stewart, Gavin W.; Wallace, Debra J.; Wilson., Robert D.

Book ID
121424362
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
370 KB
Volume
17
Category
Article
ISSN
1083-6160

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Development of a Large Scale Asymmetric
Development of a Large Scale Asymmetric Synthesis of Vanilloid Receptor (TRPV1) Antagonist ABT-102
โœ Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatram ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 104 KB

A highly efficient asymmetric synthesis of TRPV1 antagonist ABT-102 was developed and successfully demonstrated on a multi-kilogram scale. This process incorporates a new asymmetric synthesis of (R)-tert-butylaminoindan, which is based on a chiral auxiliary induced diastereoselective reduction of it

Synthesis of a TRPV1 Receptor Antagonist
Synthesis of a TRPV1 Receptor Antagonist
โœ Yu, Su; Haight, Anthony; Kotecki, Brian; Wang, Lei; Lukin, Kirill; Hill, David R ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 749 KB