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An Expedient and Multikilogram Synthesis of a Naphthalenoid H3 Antagonist

✍ Scribed by Pu, Yu-Ming; Ku, Yi-Yin; Grieme, Timothy; Black, Lawrence A.; Bhatia, Ashok V.; Cowart, Marlon

Book ID
111892881
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
207 KB
Volume
11
Category
Article
ISSN
1083-6160

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A Highly Efficient Synthesis of a Naphth
A Highly Efficient Synthesis of a Naphthalenoid Histamine-3 Antagonist
✍ Yi-Yin Ku; Tim Grieme; Yu-Ming Pu; Ashokβ€…V. Bhatia πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 244 KB πŸ‘ 2 views

## Abstract A highly efficient synthesis of the potent and selective histamine‐3 receptor antagonist **1A** was accomplished in four chemical steps and a salt formation step in 36% overall yield from 6‐bromo‐2‐naphthalenol **9**. The key features are a regioselective Suzuki coupling protocol for se