✦ LIBER ✦

Synthesis of a template-associated peptide designed as a transmembrane ion channel former

✍ Scribed by Laurent Chaloin; Jean Méry; Nicole Van Mau; Gilles Divita; Frédéric Heitz

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 219 KB
Volume: 5
Category: Article
ISSN: 1075-2617
DOI: 10.1002/(sici)1099-1387(199909)5:9<381::aid-psc206>3.0.co;2-l

No coin nor oath required. For personal study only.

✦ Synopsis

We describe the design and the Fmoc/tBu solid phase synthesis of a 20 residue long peptide containing five regularly distributed lysines. Cyclization of this peptide was achieved using BOP as coupling agent. After side-chain deprotection, all the basic residues were iodoacetylated and then allowed to react either with a C-terminal free COOH peptide or with peptides bearing a cysteamide group. The final pentameric templates were identified by mass and amino acid analysis which gave data compatible with the expected values.

📜 SIMILAR VOLUMES

Apamin as a Template for Structure-Based

Apamin as a Template for Structure-Based Rational Design of Potent Peptide Activators of p53

✍ Chong Li; Marzena Pazgier; Min Liu; Wei-Yue Lu; Wuyuan Lu 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 571 KB

Apamin as a Template for Structure-Based

Apamin as a Template for Structure-Based Rational Design of Potent Peptide Activators of p53

✍ Chong Li; Marzena Pazgier; Min Liu; Wei-Yue Lu; Wuyuan Lu 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 571 KB

Steroid Template Associated Peptides: De

Steroid Template Associated Peptides: Design, Synthesis and 2D NMR Characterization of a Novel Protected 18-Phe,19-Gly-Containing Steroidal Compound.

✍ Mira S. Bjelakovic; Natalija M. Krstic; Nenad Juranic; Milan M. Dabovic; Svetisl 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 11 KB

Topological templates as tool in molecul

Topological templates as tool in molecular recognition and peptide mimicry: Synthesis of a TASK library

✍ Ursula Silla; Manfred Mutter 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 567 KB

Topological templates disposing orthogonally protected reactive sites in defined spatial positions of a variable degree of flexibility can serve as a pool for the selective functionalization by groups thought to interact with an acceptor molecule. This strategy is exemplified by the chemo-selective

Design, Synthesis, and Ion-Transport Pro

Design, Synthesis, and Ion-Transport Properties of a Novel Family of Cyclic, Adamantane-Containing Cystine Peptides

✍ Dr. Darshan Ranganathan; V. Haridas; Dr. K. P. Madhusudanan; Dr. Raja Roy; Dr. R 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 365 KB 👁 2 views

nisorp 360CX Sorptometer operated under continuous adsorption conditions. "AI MAS NMR spectra were obtained with a Varian VXR-400 NMR spectrometer equipped with a Varian MAS probe and SiN rotor. The spectrometer frequency was 104.22 MHz. pulse width 2 ms, and sample spinning rate 6550 Hz

ChemInform Abstract: Design and Efficien

ChemInform Abstract: Design and Efficient Synthesis of A-278637 Derivatives as Potential Potassium Channel Opener.

✍ Tuanjie Li; Xiaodong Feng; Changsheng Yao; Chenxia Yu; Bei Jiang; Shujiang Tu 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 25 KB 👁 1 views

## Abstract Following a promising scaffold, a series of novel thieno[3,2‐b]quinoline derivatives (IV) are synthesized by one‐pot three‐component reaction under solvent‐ and catalyst‐free conditions.