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Apamin as a Template for Structure-Based Rational Design of Potent Peptide Activators of p53

✍ Scribed by Chong Li; Marzena Pazgier; Min Liu; Wei-Yue Lu; Wuyuan Lu

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 571 KB
Volume: 48
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200904550

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## Abstract Previously reported rates of reaction between six mutant strains of the enzyme horseradish peroxidase (HRP) and a test substrate, 2‐methoyxpyhenol, were found to correlate with characteristic binding distances computed using molecular simulation. The correlation (__R__^2^ = 0.86) bears