Topological templates as tool in molecular recognition and peptide mimicry: Synthesis of a TASK library
✍ Scribed by Ursula Silla; Manfred Mutter
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 567 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0952-3499
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✦ Synopsis
Topological templates disposing orthogonally protected reactive sites in defined spatial positions of a variable degree of flexibility can serve as a pool for the selective functionalization by groups thought to interact with an acceptor molecule. This strategy is exemplified by the chemo-selective ligation of amino-acid residues to a cyclic peptide as a structural motif (template-assembled side chains; TASK) applying the concept of combinatorial libraries. Binding assays to a monoclonal antibody allow for the delineation of a lead compound mimicking the structural features of a discontinuous epitope. The conceptually novel approach may serve as a tool in molecular recognition studies and in drug development.