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Synthesis of a spin-labelled monoacylglycerol

✍ Scribed by E.M. Fransen-Zeilstra; J.P. Ward

Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 227 KB
Volume: 38
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(85)90031-3

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✦ Synopsis

Spin-labelled lipids are used in electron spin resonance (ESR) spectroscopy for studying microenvironments within biological membranes. Various classes are available, based on the use of N-oxyldimethyloxazolidinyl (or similar groups) as spin label. The synthesis is described of a new type of spin-labelled lipid, in which a monoacylglycerol is the lipid moiety. This compound was obtained (in 58% yield of theory) by reacting 12-(N-oxyldimethyloxazolidinyl)stearic acid with glycidol in aqueous sodium chloride at 900C. The product was uniform on TLC and its identity was confirmed by IR and ESR spectroscopy.

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