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Synthesis of a radiolabelled new oral cephalosporin, E1101

✍ Scribed by Shigeto Negi; Yuki Komatsu; Akihiko Tsuruoka; Yuji Uemura

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
443 KB
Volume
38
Category
Article
ISSN
0022-2135

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✦ Synopsis

The new broad-spectrum oral antibacterial agent, E1101, has been labelled in the C-2 position of the aminothiazole ring using [ 14C]thiourea. The cephalosporin analog was synthesized in 5 steps and is suitable for metabolism and disposition studies.

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